Description

2'-Deoxy-2'-Fluoro-L-Uridine is a fluorinated nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer agents, particularly in the development of oligonucleotide therapeutics. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity intermediates for cutting-edge drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of modified oligonucleotides for antisense and siRNA therapies.
• Antiviral Drug Development: Used in research for creating nucleoside analogs targeting viral polymerases.
• Oncology Research: Investigated as a component in prodrugs and targeted cancer therapeutics.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleic acid metabolism.
• Diagnostic Probe Synthesis: Utilized in the creation of labeled nucleotides for molecular diagnostics and imaging.
• Fine Chemical Synthesis: Acts as a specialized chiral building block for complex organic molecules.

Basic Information

Product Name	2'-Deoxy-2'-Fluoro-L-Uridine
CAS No.	622785-69-7
Molecular Formula	C9H11FN2O5
Molecular Weight	246.19 g/mol
Synonyms	2'-Fluoro-2'-deoxy-L-uridine; 1-((2R,3S,5R)-3-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; L-2'-FdU; 2'-F-2'-deoxy-L-uridine; β-L-2'-Deoxy-2'-fluorouridine; (2'R)-2'-Deoxy-2'-fluorouridine (L-enantiomer); 2'-Fluoro-2'-deoxy-β-L-uridine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoro-L-Uridine is produced under strict quality management systems. We offer material suitable for research and development use, with specifications typically meeting or exceeding 98.0% purity (HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.