Description

Acetic Acid, 2-[[Tris(1-Methylethyl)Silyl]Oxy]-, Hydrazide is a specialized organosilicon-protected hydrazide derivative, serving as a critical synthetic intermediate and protecting group reagent in advanced organic synthesis. Its value lies in enabling complex multi-step reactions, particularly in the synthesis of sensitive pharmaceutical compounds and fine chemicals, by offering selective reactivity and enhanced stability for functional groups. This high-purity building block is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for innovative molecule creation.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing hydrazide functionalities in a protected manner.
• Peptide & Protein Chemistry: Used in the modification and conjugation of biomolecules, leveraging the hydrazide group for selective ligation strategies.
• Protecting Group Reagent: The tris(isopropyl)silyl (TIPS) group provides robust protection for hydroxyl or carboxyl groups during complex multi-step synthetic sequences.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific hydrazide motifs.
• Material Science Research: Employed in the development of novel polymers, dendrimers, and functionalized surfaces where controlled chemical linkage is required.
• Cross-coupling & Catalysis: Serves as a precursor or ligand in metal-catalyzed reactions for constructing carbon-heteroatom bonds.

Basic Information

Item	Detail
Product Name	Acetic Acid, 2-[[Tris(1-Methylethyl)Silyl]Oxy]-, Hydrazide
CAS No.	622373-93-7
Molecular Formula	C11H26N2O2Si
Molecular Weight	246.42 g/mol
Synonyms	2-[(Triisopropylsilyl)oxy]acetohydrazide; Acetic acid, 2-[(triisopropylsilyl)oxy]-, hydrazide; TIPS-O-acetohydrazide; (Triisopropylsilyloxy)acetohydrazide; N'-[2-(Triisopropylsilyloxy)acetyl]hydrazine; 2-(Triisopropylsiloxy)acetohydrazide; Acetohydrazide, 2-(triisopropylsilyl)oxy]-; 622373-93-7
EINECS	Contact for details

Quality Control

Our Acetic Acid, 2-[[Tris(1-Methylethyl)Silyl]Oxy]-, Hydrazide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to cGMP and ISO standards ensures traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.