Description

4-(3-Chloro-2-Fluorophenylamino)-7-Methoxyquinazolin-6-Yl Acetate Hydrochloride is a high-purity pharmaceutical intermediate and research chemical. This compound is a key synthetic precursor in the development of targeted kinase inhibitors, offering significant value for advanced pharmaceutical research and manufacturing. It is primarily utilized by R&D scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel quinazoline-based kinase inhibitors for oncology research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development stages for potential therapeutic agents.
• Biochemical Research: Serves as a reference standard and a tool compound in enzymatic and cellular assays to study signal transduction pathways.
• Preclinical Studies: Employed in the formulation of compounds for pharmacological and toxicological evaluation.
• Process Chemistry & Scale-Up: Used to optimize synthetic routes and manufacturing processes for advanced pharmaceutical compounds.

Basic Information

Product Name	4-(3-Chloro-2-Fluorophenylamino)-7-Methoxyquinazolin-6-Yl Acetate Hydrochloride
CAS No.	612501-80-1
Molecular Formula	C18H16ClFN3O3 • HCl
Molecular Weight	412.25 g/mol (Free base: 375.79 g/mol)
Synonyms	4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate hydrochloride; 6-Acetoxy-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazoline hydrochloride; BIBX 1382 dihydrochloride (common research name); N-(3-Chloro-2-fluorophenyl)-7-methoxy-6-(acetyloxy)-4-quinazolinamine hydrochloride; EGFR Inhibitor intermediate; Quinazoline derivative hydrochloride salt.
EINECS	Contact for details

Quality Control

Our production of 4-(3-Chloro-2-Fluorophenylamino)-7-Methoxyquinazolin-6-Yl Acetate Hydrochloride adheres to stringent quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.