Description

Icotinib is a highly selective, small-molecule tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR). This compound is of significant commercial and research interest due to its potent activity in blocking signaling pathways critical for cell proliferation and survival. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of targeted cancer therapies, particularly for non-small cell lung cancer (NSCLC).

Application

• Active Pharmaceutical Ingredient (API) in targeted oncology medications.
• Pharmaceutical Intermediates for the synthesis of advanced drug formulations.
• Biochemical Research as a reference standard in EGFR-related signal transduction studies.
• Preclinical Development for investigating efficacy and pharmacokinetics in cancer models.
• Formulation Development for creating oral dosage forms such as tablets and capsules.
• Contract Manufacturing for companies requiring GMP-grade active substances.

Basic Information

Product Name	Icotinib
CAS No.	610798-31-7
Molecular Formula	C22H21N3O4
Molecular Weight	391.42 g/mol
Synonyms	BPI-2009H; Conmana; Icotinib Hydrochloride; 4-[(3-Ethynylphenyl)amino]-6,7-benzo-12-crown-4-quinazoline; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; BPI-2009
EINECS	Contact for details

Quality Control

Our Icotinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as identity, purity, and impurity profiles. We support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.