Description

4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(1-Cyano-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is of significant commercial importance as a key building block in the synthesis of targeted anticancer therapies, particularly tyrosine kinase inhibitors. It is primarily required by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the production of novel oncology drugs.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of small-molecule kinase inhibitors for targeted cancer treatment.
• Oncology Drug Research: Used in R&D for developing novel therapeutics targeting specific cancer cell pathways.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for biochemical studies on kinase enzyme function and inhibition.

Basic Information

Product Name	4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(1-Cyano-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline
CAS No.	609767-58-0
Molecular Formula	C21H20ClFN6O2
Molecular Weight	442.87 g/mol
Synonyms	6-(1-Cyano-4-piperidinyloxy)-4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazoline; 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(1-cyano-4-piperidinyl)oxy]-7-methoxyquinazoline; BIBW 2992 Intermediate; Afatinib Impurity/Intermediate; Tovok Intermediate; Giotrif Intermediate; Gilotrif Intermediate; Tyrosine Kinase Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our production of 4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(1-Cyano-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline adheres to stringent quality management systems. The material is manufactured and tested to meet exacting standards suitable for pharmaceutical R&D and GMP-grade synthesis. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.