Description

4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(1-Methyl-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound, with CAS number 609767-45-5, serves as a critical building block in the synthesis of targeted kinase inhibitors, offering a strategic advantage in drug discovery and development pipelines. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in producing novel therapeutic agents for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel tyrosine kinase inhibitor (TKI) drug candidates.
• Oncology Research: Used in the development and study of targeted cancer therapies that inhibit specific signaling pathways.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Development: Used for scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies of quinazoline derivatives.

Basic Information

Product Name	4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(1-Methyl-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline
CAS No.	609767-45-5
Molecular Formula	C21H22ClFN4O2
Molecular Weight	416.88 g/mol
Synonyms	6-(1-Methyl-4-piperidinyloxy)-7-methoxy-4-[(3-chloro-4-fluorophenyl)amino]quinazoline; 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(1-methyl-4-piperidinyl)oxy]-7-methoxyquinazoline; BIBW 2992 Intermediate; Afatinib Impurity; Afatinib Intermediate; Tovok Intermediate; Giotrif Intermediate; (3-Chloro-4-fluorophenyl)-[6-(1-methyl-piperidin-4-yloxy)-7-methoxy-quinazolin-4-yl]-amine
EINECS	Contact for details

Quality Control

Our 4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(1-Methyl-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.