Description

Binimetinib is a highly potent and selective small-molecule inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2), a key component of the RAS/RAF/MEK/ERK signaling pathway. This targeted therapeutic agent is critical for advancing oncology research and drug development, particularly for cancers driven by mutations in this pathway. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in preclinical and clinical-stage cancer research.

Application

• Oncology Research & Drug Development: As a key reference standard and active pharmaceutical ingredient (API) in the development of targeted cancer therapies.
• Biochemical & Cell-Based Assays: Used as a selective MEK inhibitor to study the RAS/RAF/MEK/ERK pathway's role in cell proliferation, differentiation, and survival.
• Preclinical Studies: Employed in in vitro and in vivo models to investigate efficacy, pharmacokinetics, and pharmacodynamics for melanoma and other solid tumors.
• Pharmaceutical Intermediates: Serves as a critical building block for the synthesis of novel MEK inhibitor derivatives and prodrugs.
• Clinical Trial Material (CTM): Supplied under appropriate quality standards for use in formulation development for clinical trials.
• Mechanism of Action Studies: A vital tool for elucidating resistance mechanisms and combination therapy strategies in cancer research.

Basic Information

Product Name	Binimetinib
CAS No.	606143-89-9
Molecular Formula	C17H15BrF2N4O3
Molecular Weight	441.23 g/mol
Synonyms	MEK162; ARRY-162; ARRY-438162; 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; (R)-5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide; Mektovi (Brand Name Combination)
EINECS	Contact for details

Quality Control

Our Binimetinib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, determination of related substances and impurities, and confirmation of identity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Related Substances	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.