Description

6-Thioguanine-α-2,3-Dideoxy-3-(Hydroxymethyl)-D-Erythro-Pentafuranose is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate and building block for the creation of novel antiviral and anticancer agents, particularly in the field of nucleoside chemistry. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers focused on developing next-generation therapeutics, including prodrugs and targeted nucleotide analogs.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor for compounds designed to inhibit tumor cell proliferation by interfering with DNA/RNA synthesis.
• Biochemical Tool: Utilized in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies to optimize the efficacy and selectivity of therapeutic candidates.
• Process Development: Employed in scaling up synthetic routes for GMP-grade production of advanced therapeutic molecules.

Basic Information

Product Name	6-Thioguanine-α-2,3-Dideoxy-3-(Hydroxymethyl)-D-Erythro-Pentafuranose
CAS No.	69828-00-8
Molecular Formula	C11H15N5O4S
Molecular Weight	313.33 g/mol
Synonyms	6-Thioguanine-α-2',3'-dideoxy-3'-C-hydroxymethyl-D-erythro-pentofuranoside; 6-Thioguanosine analog, 2',3'-dideoxy-3'-hydroxymethyl; 2',3'-Dideoxy-3'-C-(hydroxymethyl)-6-thioguanosine; 6-Thio-2',3'-dideoxy-3'-C-hydroxymethylguanosine; α-6-Thioguanine-2',3'-dideoxy-3'-hydroxymethyl nucleoside; 69828-00-8; Thioguanine dideoxy hydroxymethyl derivative
EINECS	Contact for details

Quality Control

Our 6-Thioguanine-α-2,3-Dideoxy-3-(Hydroxymethyl)-D-Erythro-Pentafuranose is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.