Description

1-(5-o-Phosphono-β-D-Ribofuranosyl)Pyrimidin-2(1H)-One is a high-purity nucleoside monophosphate analog, a critical building block in advanced biochemical research and pharmaceutical development. This compound is valued for its role as a key intermediate in the synthesis of modified nucleotides and potential therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery, enzymology studies, and the development of novel molecular probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, and other nucleotide-processing enzymes.
• Proteomics & Molecular Biology: Employed in the development of labeled nucleotides for tracing metabolic pathways or for incorporation into oligonucleotides.
• Diagnostic Reagent Development: Serves as a raw material for creating specialized reagents used in diagnostic assays and research kits.
• Academic Research: Utilized in universities and research institutes for fundamental studies on nucleic acid chemistry and metabolism.

Basic Information

Product Name	1-(5-o-Phosphono-β-D-Ribofuranosyl)Pyrimidin-2(1H)-One
CAS No.	69776-97-2
Molecular Formula	C9H13N2O9P
Molecular Weight	324.18 g/mol
Synonyms	2'-Deoxyuridine 5'-monophosphate (dUMP) analog; Uridine 5'-monophosphonate; 5-Phosphonouridine; 1-(5-O-Phosphono-β-D-ribofuranosyl)uracil; 2(1H)-Pyrimidinone, 1-(5-O-phosphono-β-D-ribofuranosyl)-; β-d-Ribofuranose, 1-(2-oxo-1(2H)-pyrimidinyl)-, 5-(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 1-(5-o-Phosphono-β-D-Ribofuranosyl)Pyrimidin-2(1H)-One is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.