Description

3-p-Tolyl-Adamantane-1-Carbonyl Chloride is a high-purity, reactive chemical intermediate featuring a unique adamantane core functionalized with a tolyl group and an acid chloride moiety. This compound matters for its role as a critical building block in advanced organic synthesis, enabling the introduction of the rigid, lipophilic adamantane structure into target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by material scientists exploring advanced polymers and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, where the adamantane scaffold can enhance blood-brain barrier penetration and metabolic stability.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, where its structural properties can contribute to improved efficacy and environmental profile.
• Advanced Material Research: Acts as a monomer or cross-linking agent in the creation of high-performance polymers with enhanced thermal stability and mechanical properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create sophisticated ligands for catalytic systems.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic & Industrial R&D: Utilized in exploratory chemistry for developing new synthetic methodologies and investigating structure-activity relationships (SAR).

Basic Information

Product Name	3-p-Tolyl-Adamantane-1-Carbonyl Chloride
CAS No.	69751-96-8
Molecular Formula	C18H21ClO
Molecular Weight	288.81 g/mol
Synonyms	1-Adamantanecarbonyl chloride, 3-(4-methylphenyl)-; 3-(4-Methylphenyl)adamantane-1-carbonyl chloride; 3-p-Tolyl-1-adamantanecarbonyl chloride; 3-(p-Tolyl)adamantane-1-carbonyl chloride; 3-(4-Methylphenyl)tricyclo[3.3.1.1³,⁷]decane-1-carbonyl chloride; 69751-96-8; Adamantane derivative, 3-p-tolyl-1-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 3-p-Tolyl-Adamantane-1-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.