Description

D-Ribofuranose, 2,3,5-Tris-o-(Trimethylsilyl)-, Bis(Trimethylsilyl) Phosphate is a highly functionalized, silyl-protected ribose derivative that serves as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in providing a reactive, protected scaffold for the precise construction of complex nucleoside analogs and other bioactive molecules. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for antiviral and anticancer drug discovery, as well as in specialized oligonucleotide synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA/DNA backbones for research tools, diagnostics, and therapeutic oligonucleotides.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by allowing selective modification of the ribose sugar moiety.
• Prodrug Development: Serves as a precursor for prodrug strategies aimed at improving the bioavailability and pharmacokinetics of nucleoside-based therapeutics.
• Chemical Biology Probes: Facilitates the creation of labeled or tagged nucleotide derivatives for studying biological processes.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	D-Ribofuranose, 2,3,5-Tris-o-(Trimethylsilyl)-, Bis(Trimethylsilyl) Phosphate
CAS No.	69688-46-6
Molecular Formula	C21H53O8PSi5
Molecular Weight	625.12 g/mol
Synonyms	2,3,5-Tri-O-(trimethylsilyl)-D-ribofuranosyl bis(trimethylsilyl) phosphate; D-Ribofuranose, 2,3,5-tris-O-(trimethylsilyl)-, bis(trimethylsilyl) phosphate; Tris-O-TMS-ribofuranosyl bis-TMS phosphate; Protected ribose phosphate; Silylated ribofuranose phosphate ester; TMS-ribose-TMS phosphate; Nucleoside synthesis intermediate
EINECS	Contact for details

Quality Control

Every batch of D-Ribofuranose, 2,3,5-Tris-o-(Trimethylsilyl)-, Bis(Trimethylsilyl) Phosphate is produced and tested under strict quality management protocols to ensure consistency and reliability for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR (¹H & ¹³C) for structural confirmation, and identity verification by IR spectroscopy. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.