Description

4,4'-Dithiobis[(2S)-2-(Trimethylsilyl)Aminobutyric Acid Trimethylsilyl] Ester is a sophisticated organosilicon compound featuring a disulfide bridge and chiral, silyl-protected amino acid ester functionalities. This unique molecular architecture makes it a valuable advanced intermediate for the synthesis of complex peptides and bioactive molecules where precise stereochemistry and orthogonal protecting groups are critical. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing novel therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of chiral peptides and peptidomimetics with disulfide linkages.
• Proteomics Research: Used in the development of chemical probes and activity-based protein profiling (ABP) reagents targeting cysteine proteases.
• Bioconjugation Chemistry: Serves as a specialized linker or functional handle for site-specific protein and antibody-drug conjugate (ADC) modifications.
• Material Science: Potential monomer or cross-linking agent for creating novel silicon-containing polymers with redox-responsive properties.
• Catalyst Ligand Synthesis: Intermediate for preparing chiral ligands used in asymmetric catalysis.
• Academic & Industrial R&D: Employed in exploratory chemistry for developing new synthetic methodologies and bioactive compounds.

Basic Information

Product Name	4,4'-Dithiobis[(2S)-2-(Trimethylsilyl)Aminobutyric Acid Trimethylsilyl] Ester
CAS No.	69688-45-5
Molecular Formula	C24H56N2O4S2Si4
Molecular Weight	621.25 g/mol
Synonyms	Bis(trimethylsilyl) (2S)-2-[[(trimethylsilyl)amino]-4,4'-dithiobis(butanoate); L-2-[[(Trimethylsilyl)amino]butanoic acid, 4,4'-dithiobis-, bis(trimethylsilyl) ester; (2S)-2-[[(Trimethylsilyl)amino]butanoic acid 4,4'-dithiodi- bis(trimethylsilyl) ester; Silylated Cystine Derivative; TMS-Protected Cystine Analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of our 4,4'-Dithiobis[(2S)-2-(Trimethylsilyl)Aminobutyric Acid Trimethylsilyl] Ester is produced and controlled under a strict quality management system. We ensure high chiral purity and chemical integrity through advanced analytical techniques including HPLC, GC, and NMR. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.