Description

3,11β-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One is a key organosilicon-protected steroid derivative, specifically a silyl ether of estradiol. This compound is of significant value as a versatile synthetic intermediate in advanced pharmaceutical research and development, offering enhanced stability and solubility for complex chemical transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel steroid-based therapeutics and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel steroidal drugs and hormone analogs.
• Research Chemical: Used in academic and industrial laboratories for studying steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Process Chemistry: Serves as a protected intermediate in multi-step synthetic routes, leveraging the trimethylsilyl (TMS) groups for selective reactions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Fine Chemical Synthesis: Used in the production of high-purity, specialty steroids for various applications.

Basic Information

Product Name	3,11β-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One
CAS No.	69688-38-6
Molecular Formula	C24H40O3Si2
Molecular Weight	432.75 g/mol
Synonyms	3,11β-Bis(trimethylsilyloxy)estra-1,3,5(10)-trien-17-one; Estra-1,3,5(10)-triene-3,11β-diol, 17-oxo-, 3,11-bis(trimethylsilyl) ether; 11β,17β-Dihydroxyestra-1,3,5(10)-trien-3-yl trimethylsilyl ether (related); Silylated Estradiol Derivative; TMS-Protected Estradiol Intermediate; 69688-38-6; Estratrien-17-one, 3,11β-bis(trimethylsiloxy)-1,3,5(10)-
EINECS	Contact for details

Quality Control

Our 3,11β-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.