Description

Tetrahydro-Furan-3-Carbonyl Chloride is a versatile and highly reactive acid chloride derivative of tetrahydrofuran, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the tetrahydrofuran-3-carbonyl moiety, enabling the construction of complex molecules with specific stereochemistry and functional properties. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fused or substituted tetrahydrofuran rings.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that incorporate heterocyclic scaffolds for enhanced bioactivity.
• Peptide Mimetics & Drug Discovery: Employed to create peptidomimetics and other bioactive compounds by acylating amino groups or other nucleophiles.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for synthesizing specialty polymers with unique thermal or mechanical properties.
• Ligand & Catalyst Development: Useful for preparing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	Tetrahydro-Furan-3-Carbonyl Chloride
CAS No.	69595-02-4
Molecular Formula	C5H7ClO2
Molecular Weight	134.56 g/mol
Synonyms	3-Tetrahydrofurancarbonyl chloride; Tetrahydro-3-furoyl chloride; 3-Furoyl chloride, tetrahydro-; Oxolane-3-carbonyl chloride; 3-Carboxy-tetrahydrofuran chloride; THF-3-carbonyl chloride; 3-Tetrahydrofuroyl chloride
EINECS	Contact for details

Quality Control

Our Tetrahydro-Furan-3-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assessment and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.