Description

1-(3'-Amino-3'-Carboxypropyl)Uracil is a specialized nucleobase derivative, a key intermediate in the synthesis of modified nucleotides and oligonucleotides. This compound matters for its role in creating advanced biomolecules with tailored properties for research and therapeutic applications. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on nucleic acid chemistry, antisense technology, and the development of novel diagnostics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside analogs and oligonucleotide therapeutics.
• Antisense Oligonucleotide (ASO) Development: Used to incorporate modified bases that enhance the stability and binding affinity of ASOs for targeted gene silencing.
• siRNA and miRNA Research: Serves as a precursor for modified RNA strands to improve nuclease resistance and pharmacokinetic profiles.
• Diagnostic Probe Synthesis: Employed in the creation of labeled nucleic acid probes for sensitive detection and diagnostic assays.
• Bioconjugation: The amino and carboxyl functional groups enable site-specific conjugation to peptides, proteins, or reporter molecules.
• Academic & Industrial R&D: A valuable tool for fundamental research in nucleic acid structure, function, and drug discovery.

Basic Information

Product Name	1-(3'-Amino-3'-Carboxypropyl)Uracil
CAS No.	69557-82-0
Molecular Formula	C8H11N3O4
Molecular Weight	213.19 g/mol
Synonyms	N1-(3-Amino-3-carboxypropyl)uracil; 3-(Uracil-1-yl)-L-2,3-diaminopropionic Acid; 1-(3-Amino-3-carboxypropyl)uracil; Uracil, 1-(3-amino-3-carboxypropyl)-; ACU; L-2,3-Diamino-3-(uracil-1-yl)propanoic Acid
EINECS	Contact for details

Quality Control

Our 1-(3'-Amino-3'-Carboxypropyl)Uracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical and biotech research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.