Description

2'-o-T-Butyldimethylsilyl Adenosine is a key protected nucleoside derivative, specifically an adenosine molecule with a tert-butyldimethylsilyl (TBDMS) group at the 2'-hydroxyl position. This modification is critical for its primary role as a versatile building block in the synthesis of oligonucleotides, particularly for RNA research and therapeutic development. It is an essential intermediate for pharmaceutical companies, biotechnology research institutions, and CROs engaged in antisense technology, siRNA synthesis, and nucleotide chemistry.

Application

• Oligonucleotide Synthesis: A fundamental phosphoramidite precursor for solid-phase synthesis of RNA and modified oligonucleotides.
• Antisense & siRNA Therapeutics: Used in the research and production of siRNA and antisense oligonucleotides for targeted gene silencing.
• Medicinal Chemistry: Serves as a protected intermediate in the development of nucleoside-based prodrugs and antiviral agents.
• Biochemical Research: Employed in studies of RNA structure, function, and enzyme mechanisms requiring site-specifically modified nucleotides.
• Diagnostic Probe Development: Used to create labeled nucleotide probes for detection and diagnostic applications.

Basic Information

Product Name	2'-o-T-Butyldimethylsilyl Adenosine
CAS No.	69504-13-8
Molecular Formula	C₁₇H₂₉N₅O₄Si
Molecular Weight	395.53 g/mol
Synonyms	2'-O-(tert-Butyldimethylsilyl)adenosine; 2'-O-TBDMS-Adenosine; 9-[(2R,3R,4R,5R)-5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3,4-dihydroxyoxolan-2-yl]-6-aminopurine; Adenosine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 2'-O-(tert-Butyldimethylsilyl)-adenosine; TBDMS-Adenosine; 2'-O-TBDMS-Ado
EINECS	Contact for details

Quality Control

Our 2'-o-T-Butyldimethylsilyl Adenosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive pharmaceutical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.