Description

2',3'-Bis-(o-T-Butyldimethylsilyl)Uridine is a key protected nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis and pharmaceutical research. This compound is crucial for researchers and manufacturers requiring precise control over ribose hydroxyl group reactivity, enabling the synthesis of complex RNA analogs and therapeutic oligonucleotides. It is an essential building block for the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics in the biotechnology and pharmaceutical industries.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of RNA and modified RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• siRNA and miRNA Synthesis: Serves as a protected monomer for constructing small interfering RNA (siRNA) and microRNA (miRNA) molecules.
• Pharmaceutical Intermediates: Acts as a high-value intermediate in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Employed in academic and industrial labs for studying RNA structure, function, and metabolism.
• Diagnostic Probe Synthesis: Used to create labeled RNA probes for diagnostic assays and genomic research.

Basic Information

Product Name	2',3'-Bis-(o-T-Butyldimethylsilyl)Uridine
CAS No.	69504-12-7
Molecular Formula	C21H40N2O6Si2
Molecular Weight	472.73 g/mol
Synonyms	2',3'-Bis-O-(tert-Butyldimethylsilyl)uridine; 2',3'-Di-O-(tert-butyldimethylsilyl)uridine; 2',3'-Bis-O-TBDMS-uridine; Uridine, 2',3'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-; 2',3'-Bis(tert-butyldimethylsilyloxy)uridine; 2',3'-Di-O-TBDMS-U; TBDMS-protected uridine; 2',3'-Di-O-(tert-butyldimethylsilyl)-uridine
EINECS	Contact for details

Quality Control

Our 2',3'-Bis-(o-T-Butyldimethylsilyl)Uridine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive pharmaceutical and research applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry verification. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.