Description

N6-Benzoyl-2'-o-(tert-Butyldimethylsilyl)Adenosine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, chemically modified building blocks for nucleic acid chemistry. It is primarily utilized in the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acid analogs within the pharmaceutical and biotechnology sectors.

Application

• Solid-Phase Oligonucleotide Synthesis: Serves as a protected phosphoramidite precursor for the automated synthesis of DNA/RNA strands.
• Antisense & siRNA Therapeutic Development: A crucial building block in the manufacture of modified oligonucleotides for gene silencing and therapeutic applications.
• Medicinal Chemistry & Drug Discovery: Used in research for creating novel nucleoside-based prodrugs and investigating structure-activity relationships.
• Bioconjugation & Probe Synthesis: Enables the site-specific introduction of adenosine derivatives into biomolecules or fluorescent probes for diagnostic assays.
• Process Development & Scale-Up: Supports the transition from laboratory-scale research to GMP-compliant manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	N6-Benzoyl-2'-o-(tert-Butyldimethylsilyl)Adenosine
CAS No.	69504-07-0
Molecular Formula	C24H33N5O5Si
Molecular Weight	499.65 g/mol
Synonyms	2'-O-TBDMS-N6-Benzoyladenosine; N6-Benzoyl-2'-O-(tert-butyldimethylsilyl)adenosine; 9-[(2R,3R,4R,5R)-5-[[(tert-Butyldimethylsilyl)oxy]methyl]-3,4-dihydroxyoxolan-2-yl]-N-benzoyladenine; 2'-O-TBDMS-A(Bz); Adenosine, N6-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; N6-Bz-2'-O-TBDMS-adenosine; Protected Adenosine Derivative
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-2'-o-(tert-Butyldimethylsilyl)Adenosine is produced under stringent quality management systems to ensure batch-to-batch consistency for critical research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically verified by HPLC, NMR, and mass spectrometry. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.