Description

Pyrenesulfonyl Azide is a specialized organic azide derivative of pyrene, a polycyclic aromatic hydrocarbon. This compound serves as a critical photoaffinity labeling reagent and a versatile precursor for "click chemistry" reactions, enabling the selective modification and study of complex biomolecules and materials. It is essential for researchers and manufacturers in the fields of chemical biology, materials science, and pharmaceutical development who require high-purity, reactive intermediates for advanced synthesis and labeling applications.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalently tagging biological targets (e.g., proteins, enzymes, receptors) upon UV irradiation to study binding sites and interactions.
• Click Chemistry: Acts as a sulfonyl azide component in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for bioconjugation.
• Polymer and Surface Functionalization: Used to introduce reactive azide groups onto polymer chains or material surfaces for subsequent modification with alkyne-bearing molecules.
• Proteomics and Chemical Proteomics: Employed in activity-based protein profiling (ABPP) to identify and characterize enzyme activities within complex proteomes.
• Materials Science Research: Facilitates the development of novel functional materials, such as sensors or smart polymers, through controlled cross-linking or tagging.
• Synthesis of Heterocyclic Compounds: Serves as a building block in the synthesis of triazoles and other nitrogen-containing heterocycles with potential biological activity.

Basic Information

Product Name	Pyrenesulfonyl Azide
CAS No.	69489-90-3
Molecular Formula	C₁₇H₉N₃O₂S
Molecular Weight	319.34 g/mol
Synonyms	1-Pyrenesulfonyl azide; Pyrene-1-sulfonyl azide; 1-Pyrenesulfonazide; PSA; Pyrenesulfonazide; Azidopyrene sulfonate; 1-Azidosulfonylpyrene; Pyrene sulfonyl azide
EINECS	Contact for details

Quality Control

Our Pyrenesulfonyl Azide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR) for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and potential thermal instability, prolonged exposure to light or heat should be avoided. Keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (e.g., DMSO, DMF, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.