Description

N(2),N(6)-Dimethyl-9-Hydroxyellipticinium is a synthetic derivative of the natural alkaloid ellipticine, belonging to the class of cytotoxic agents. This compound is valued for its potent biological activity, primarily as a topoisomerase II inhibitor and DNA intercalator, making it a critical intermediate in pharmaceutical research and development. It is essential for researchers and manufacturers in the oncology drug discovery and preclinical studies sectors, where high-purity chemical entities are required to investigate novel therapeutic mechanisms.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced anti-cancer drug candidates.
• Biochemical Research: Used as a reference standard and active compound in studies of topoisomerase inhibition and DNA interaction mechanisms.
• Oncology Drug Discovery: A vital tool for in vitro and in vivo screening of cytotoxic activity against various cancer cell lines.
• Mechanistic Studies: Employed to investigate apoptosis induction and cell cycle arrest in experimental pharmacology.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and molecular biology.
• Preclinical Development: Supports formulation studies and pharmacokinetic profiling of new ellipticine-derived therapeutics.

Basic Information

Product Name	N(2),N(6)-Dimethyl-9-Hydroxyellipticinium
CAS No.	69467-90-9
Molecular Formula	C21H20N2O+
Molecular Weight	316.40 g/mol
Synonyms	9-Hydroxy-2,6-dimethylellipticinium; 9-Hydroxy-N2,N6-dimethylellipticinium; 9-OH-2,6-DME; Elliptinium derivative; NSC-264137; Datelliptium; Celliptium (as salt form); 5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
EINECS	Contact for details

Quality Control

Our N(2),N(6)-Dimethyl-9-Hydroxyellipticinium is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.