Description

1-Piperazinecarbonyl Chloride (9Ci) is a versatile and highly reactive acyl chloride derivative of piperazine, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the piperazinecarbonyl moiety, a key structural feature in numerous pharmacologically active compounds. This intermediate is essential for research and production in the pharmaceutical industry, particularly for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of various drug candidates and active pharmaceutical ingredients (APIs), especially those containing piperazine scaffolds.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where the piperazinecarbonyl group imparts specific biological activity.
• Peptide Mimetics & Linker Chemistry: Employed in medicinal chemistry for creating peptide analogs and as a reagent for constructing molecular linkers in bioconjugation.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored properties.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new chemical entities and reaction pathways.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Item	Detail
Product Name	1-Piperazinecarbonyl Chloride (9Ci)
CAS No.	69433-07-4
Molecular Formula	C5H9ClN2O
Molecular Weight	148.59 g/mol
Synonyms	Piperazine-1-carbonyl chloride; Piperazine-1-carboxylic acid chloride; 1-Piperazinecarboxylic acid chloride; 1-Piperazinecarbonyl chloride; Piperazinecarbonyl chloride; Carbonic acid, piperazinium-1-, chloride; NSC 401119; UNII-4K8V5W3W0F
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and fine chemical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.