Description

13-cis-Acitretin is a synthetic second-generation retinoid and a key isomer of the active metabolite of etretinate. This compound is of significant interest in pharmaceutical research and development due to its potent biological activity in modulating cell differentiation and proliferation. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel dermatological and oncological therapeutics. The material is supplied to meet the stringent purity requirements of advanced R&D and process development.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and research of retinoid-based APIs for treating severe skin disorders.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate retinoid receptor pathways, gene expression, and cellular differentiation mechanisms.
• Dermatology Drug Development: A key compound for R&D targeting conditions like psoriasis, severe acne, and other keratinization diseases.
• Oncology Research: Studied for its potential effects on cancer cell growth inhibition and apoptosis in certain malignancies.
• Metabolite Studies: Used as an analytical standard in pharmacokinetic and metabolic profiling studies of related retinoid drugs.

Basic Information

Product Name	13-cis-Acitretin
CAS No.	69427-46-9
Molecular Formula	C21H26O3
Molecular Weight	326.43 g/mol
Synonyms	13-cis-Acitretin; (2Z,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic Acid; Neotigason (cis-isomer); cis-Acitretin; Isotretinoin analogue; Ro 13-7652/000 (cis); All-trans-Acitretin isomer
EINECS	Contact for details

Quality Control

Our 13-cis-Acitretin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation, to ensure it meets high-purity research-grade specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and related substances. We support compliance with cGMP guidelines for advanced pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.