Description

13-cis-Etretinate is a synthetic aromatic retinoid derivative, a geometric isomer of etretinate, known for its potent biological activity. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for studying retinoid receptor pathways. It is essential for researchers and manufacturers in the pharmaceutical and life sciences sectors focused on dermatology, oncology, and cell differentiation studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for quality control (QC) and research and development (R&D) in the production of retinoid-based APIs.
• Biochemical Research: Serves as a key tool compound for investigating the mechanisms of action, metabolism, and structure-activity relationships (SAR) of retinoids.
• Dermatology Research: Applied in preclinical studies targeting skin disorders such as psoriasis, acne, and other keratinization diseases.
• Oncology Research: Utilized in studies exploring the anti-proliferative and differentiation-inducing effects of retinoids on various cancer cell lines.
• Metabolite Studies: Acts as a specific isomer for the analysis and quantification of etretinate and its metabolites in pharmacokinetic and bioanalytical research.

Basic Information

Product Name	13-cis-Etretinate
CAS No.	69427-41-4
Molecular Formula	C23H30O3
Molecular Weight	354.49 g/mol
Synonyms	13-cis-Etretinate; Isotretinoin Ester; (2Z,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic Acid Ethyl Ester; Ro 13-7652/001; 13-cis-Acitretin Ethyl Ester; Ethyl (2Z,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
EINECS	Contact for details

Quality Control

Our 13-cis-Etretinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.