Description

Amonafide is a synthetic organic compound belonging to the naphthalimide class, recognized for its potent biological activity. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the research and development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and academic research institutions focused on oncology and drug discovery. Its unique structure makes it a valuable scaffold for developing targeted cancer therapies.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel anticancer drug candidates targeting DNA topoisomerase II.
• Oncology Drug Discovery: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies for evaluating antitumor efficacy and mechanism of action.
• Biochemical Research: Employed in studies investigating DNA intercalation, apoptosis induction, and cell cycle arrest in various cancer cell lines.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and pharmacology.
• Reference Standard Manufacturing: Supplied in high-purity grades for use as a certified reference material (CRM) in analytical testing and quality control.

Basic Information

Product Name	Amonafide
CAS No.	69408-81-7
Molecular Formula	C16H17N3O3
Molecular Weight	299.33 g/mol
Synonyms	5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione; NSC 308847; Benz[de]isoquinoline-1,3-dione, 5-amino-2-[2-(dimethylamino)ethyl]-; Nafidimide; Amonafide (USAN); UNII-1K5B7CPB0Q
EINECS	Contact for details

Quality Control

Our Amonafide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.