Description

1-[3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Hydroxy-Pyrimidine-2,4-Dione is a high-purity nucleoside derivative, a critical building block in advanced pharmaceutical and biochemical research. Its precise molecular structure makes it an essential intermediate for the synthesis of novel antiviral and anticancer agents, where purity and consistency are paramount. This compound is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers developing next-generation therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nucleoside-based antiviral drugs and chemotherapeutic agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway analysis.
• Antiviral Drug Development: Serves as a core scaffold for designing compounds targeting viral polymerases.
• Molecular Biology: Utilized in the preparation of modified nucleotides for oligonucleotide synthesis.
• Diagnostic Reagent Manufacturing: Component in the production of specialized reagents for clinical diagnostics and assays.
• Academic Research: Fundamental compound for studying nucleic acid chemistry and medicinal chemistry in university and institutional labs.

Basic Information

Product Name	1-[3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Hydroxy-Pyrimidine-2,4-Dione
CAS No.	69321-95-5
Molecular Formula	C9H12N2O8
Molecular Weight	276.20 g/mol
Synonyms	5-Hydroxyuridine; 5-HO-Urd; 5-Hydroxy-2'-deoxyuridine (common misnomer, related structure); 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxypyrimidine-2,4-dione; 5-Hydroxy-1-β-D-ribofuranosyluracil; Uridine, 5-hydroxy-; 5-HO-Uridine; 5-Hydroxypseudouridine (isomeric form)
EINECS	Contact for details

Quality Control

Our 1-[3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Hydroxy-Pyrimidine-2,4-Dione is manufactured under strict quality management systems. We offer material suitable for research and development purposes, with typical purity grades exceeding 95% (HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. For cGMP-grade material or material meeting specific pharmacopeial standards (e.g., USP reference standards), please contact our technical sales team for availability and custom synthesis options.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.