Description

(+)-3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Cytidine is a high-purity, protected nucleoside derivative essential for advanced oligonucleotide synthesis. This compound serves as a critical building block, offering superior stability and selectivity in the formation of phosphodiester bonds. It is primarily required by pharmaceutical R&D teams and fine chemical manufacturers engaged in the production of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of DNA and RNA sequences.
• Antisense Drug Development: Used in the research and manufacturing of antisense oligonucleotides for therapeutic applications.
• siRNA and miRNA Synthesis: Critical for constructing short interfering RNA (siRNA) and microRNA (miRNA) strands for gene silencing studies.
• Diagnostic Probe Manufacture: Employed in the production of labeled nucleic acid probes for diagnostic assays and genomic research.
• Pharmaceutical Intermediates: Serves as a high-value intermediate in the synthesis of novel nucleoside-based antiviral or anticancer agents.
• Bioconjugation Chemistry: Utilized for site-specific modifications of nucleic acids with reporter molecules or functional groups.

Basic Information

Product Name	(+)-3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Cytidine
CAS No.	69304-42-3
Molecular Formula	C23H43N3O6Si2
Molecular Weight	513.78 g/mol
Synonyms	3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)cytidine; TIPDS-Cytidine; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[(tert-butyldimethylsilyl)]-3'-O-succinyl-cytidine; Cytidine, 3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-; 1-((2R,3R,4R,5R)-3,4-Bis((triisopropylsilyl)oxy)-5-((triisopropylsilyloxy)methyl)tetrahydrofuran-2-yl)-4-amino-2(1H)-pyrimidinone; Protected Cytidine; TIPDS-protected cytidine nucleoside
EINECS	Contact for details

Quality Control

Our (+)-3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Cytidine is manufactured under strict quality systems suitable for pharmaceutical research. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant internal specifications for advanced synthetic intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.