Description

Guanosine 5'-Phosphoimidazolide is a chemically activated nucleotide derivative, serving as a crucial intermediate in the synthesis of oligonucleotides and RNA analogs. Its primary value lies in enabling the controlled formation of phosphodiester bonds, a fundamental step in constructing nucleic acid chains for research and therapeutic applications. This high-purity biochemical is essential for pharmaceutical R&D, academic laboratories, and biotechnology companies focused on antisense technology, RNA interference (RNAi), and the development of novel diagnostics.

Application

• Oligonucleotide Synthesis: A key phosphorylating agent in solid-phase and solution-phase synthesis of DNA and RNA fragments.
• RNA Analog Production: Used in the preparation of modified nucleosides and non-natural RNA backbones for structural and functional studies.
• Biochemical Research: Serves as a substrate or intermediate in enzymatic studies and investigations into prebiotic chemistry and the origins of life.
• Antisense & RNAi Therapeutics: Critical for manufacturing research-grade antisense oligonucleotides and siRNA molecules.
• Diagnostic Probe Development: Employed in the creation of labeled nucleic acid probes for hybridization assays and detection systems.
• Catalysis Studies: Used as a model compound to study ribozyme activity and other catalytic RNA mechanisms.

Basic Information

Product Name	Guanosine 5'-Phosphoimidazolide
CAS No.	69281-33-0
Molecular Formula	C13H17N6O7P
Molecular Weight	400.29 g/mol
Synonyms	5'-Guanylyl imidodiphosphate; Guanosine 5'-monophosphorimidazolide; GMP-Imidazolide; Imidazole GTP; P1-(5'-Guanosyl) P2-imidazolyl diphosphate; Guanosine 5'-(imidazolyl phosphate); 5'-O-Phosphonatoimidazolyl Guanosine
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Phosphoimidazolide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive biochemical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for fine chemical production, and specifications can be aligned with customer-specific requirements for research or cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.