Description

Deoxyadenosine-5'-Tri-3'-Diphosphate is a specialized nucleotide analog of significant biochemical interest. This compound serves as a crucial tool in enzymatic studies and the development of nucleotide-based therapeutics. It is primarily utilized by researchers and manufacturers in the fields of molecular biology, enzymology, and pharmaceutical development. Its unique tri-diphosphate structure makes it valuable for probing enzyme mechanisms and as a potential precursor in synthetic pathways.

Application

• Enzymology Research: Used as a substrate or inhibitor in studies of DNA polymerases, kinases, and other nucleotide-processing enzymes.
• Biochemical Assay Development: Serves as a key component in high-throughput screening assays for drug discovery targeting nucleotide metabolism.
• Nucleotide Analog Synthesis: Acts as a sophisticated building block for the chemical synthesis of novel modified nucleotides with potential therapeutic applications.
• Metabolic Pathway Analysis: Employed in tracer studies to investigate deoxyadenosine triphosphate (dATP) pools and related metabolic fluxes in cellular systems.
• Pharmaceutical Intermediates: Potential use as an intermediate in the production of specialized antiviral or anticancer prodrugs.

Basic Information

Product Name	Deoxyadenosine-5'-Tri-3'-Diphosphate
CAS No.	69150-52-3
Molecular Formula	C10H17N5O13P4
Molecular Weight	607.17 g/mol
Synonyms	2'-Deoxyadenosine-5'-triphosphate-3'-diphosphate; dATP-3'-diphosphate; 5'-dATP-3'-diphosphate; Deoxyadenosine triphosphate diphosphate; Adenosine, 2'-deoxy-, 5'-(trihydrogen triphosphate), 3'-(trihydrogen diphosphate); P1,P3-Di(adenosin-5'-yl) triphosphate (related structural analog); dA(5')ppp(3')dA (abbreviated form); 2'-Deoxy-5'-adenylyl triphosphate 3'-adenylyl diphosphate
EINECS	Contact for details

Quality Control

Our Deoxyadenosine-5'-Tri-3'-Diphosphate is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry for identity verification. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support research and development applications where consistency and traceability are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment to maintain stability due to its hygroscopic and light-sensitive nature. For long-term storage, consider aliquoting under an inert atmosphere to prevent moisture uptake and degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.