Description

1-β-Arabinofuranosyl-5-Ethyluracil 5'-Triphosphate is a chemically modified nucleoside triphosphate analog, a critical building block for advanced biochemical research and pharmaceutical development. Its primary value lies in its ability to act as a substrate or inhibitor for viral polymerases, making it a key compound in the study of antiviral mechanisms and nucleic acid chemistry. This high-purity biochemical is essential for researchers and developers in antiviral drug discovery, molecular biology, and enzymology, where precise and reliable reagents are paramount.

Application

• Antiviral Research: Used as a substrate analog to study the replication mechanisms of DNA and RNA viruses, particularly herpesviruses and other viral families.
• Enzyme Kinetics & Inhibition Studies: Employed to investigate the activity and inhibition profiles of viral polymerases (e.g., DNA polymerase) and reverse transcriptases.
• Nucleic Acid Synthesis: Serves as a modified nucleotide triphosphate (NTP) for the enzymatic synthesis of labeled or modified oligonucleotides.
• Prodrug Development: Acts as a precursor or active metabolite in the development of nucleoside-based antiviral prodrugs.
• Biochemical Assay Development: Utilized as a standard or critical reagent in high-throughput screening (HTS) assays for identifying novel antiviral compounds.
• Mechanistic Studies: Applied in research to understand chain termination events and mutagenesis in nucleic acid sequences.

Basic Information

Product Name	1-β-Arabinofuranosyl-5-Ethyluracil 5'-Triphosphate
CAS No.	69150-51-2
Molecular Formula	C16H24N3O16P3
Molecular Weight	607.29 g/mol
Synonyms	5-Ethyl-araUTP; 1-β-D-Arabinofuranosyl-5-ethyluracil 5'-triphosphate; 5-Ethyl-1-β-D-arabinofuranosyluracil 5'-triphosphate; 5-Ethyl-arabinosyluracil triphosphate; Ara-EUTP; BV-araU TP; BVaraUTP; 5-Ethyl-2'-deoxy-β,1'-arabino-uridine-5'-triphosphate
EINECS	Contact for details

Quality Control

Our 1-β-Arabinofuranosyl-5-Ethyluracil 5'-Triphosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This compound is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 3.0 %
Triphosphate Content (HPLC)	≥ 85%
Di- & Monophosphate Impurities	≤ 5.0% (combined)
Biological Activity	Tested in standard enzymatic assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.