Description

2'-Fluoro-5-Chloro-1-β-D-Arabinofuranosylcytosine is a high-purity nucleoside analog, a key intermediate in the synthesis of advanced pharmaceutical compounds. This modified cytidine derivative is valued for its role in developing antiviral and anticancer therapeutics, where precise molecular structure is critical for biological activity. It is an essential building block for pharmaceutical R&D and production, particularly for researchers and manufacturers in the oncology and antiviral drug development sectors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of compounds targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a key scaffold for creating chemotherapeutic agents that interfere with DNA synthesis in cancer cells.
• Biochemical Research: Employed in studies of enzyme kinetics, nucleoside metabolism, and structure-activity relationships (SAR).
• Process Development: Used for scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Item	Details
Product Name	2'-Fluoro-5-Chloro-1-β-D-Arabinofuranosylcytosine
CAS No.	69123-92-8
Molecular Formula	C9H10ClFN3O5
Molecular Weight	291.65 g/mol
Synonyms	5-Chloro-2'-fluoro-arabinofuranosylcytosine; 2'-F-5-Cl-Ara-C; 5-Chloro-2'-fluoro-1-β-D-arabinofuranosylcytosine; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-chlorocytosine; 2'-Fluoro-5-chloro-ara-C; 5-Chloro-2'-fluoro-ara-C; 5-Chloro-2'-fluoro-1-β-D-arabinofuranosyl-cytosine; 2'-F-5-Cl-araC
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-5-Chloro-1-β-D-Arabinofuranosylcytosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.