Description

Cholesterol, Water Soluble is a chemically modified derivative of cholesterol designed for enhanced solubility in aqueous systems. This property is critical for research and formulation applications where the lipophilic nature of standard cholesterol is a limiting factor. It is an essential material for scientists and manufacturers in the life sciences, pharmaceutical development, and advanced material sectors who require precise delivery of cholesterol in aqueous media.

Application

• Liposome and Nanoparticle Formulation: A key component for creating stable, uniform liposomes and lipid nanoparticles (LNPs) used in drug delivery systems, including mRNA vaccines and cancer therapeutics.
• Cell Culture Media Supplement: Used to supplement serum-free or low-serum cell culture media, providing a necessary precursor for membrane synthesis and steroid hormone production in vitro.
• Biochemical Research: Employed in solubility studies, membrane biophysics experiments, and as a standard in analytical method development for cholesterol detection in aqueous samples.
• Diagnostic Reagent Manufacturing: Serves as a raw material or calibrant in the production of clinical diagnostic kits for cholesterol level determination in blood and other biological fluids.
• Cosmetic and Dermatological Preparations: Incorporated into advanced emulsions, creams, and lotions where its water-soluble nature improves skin delivery and formulation stability.
• Biomimetic Membrane Studies: Used to construct and study model membrane systems that more accurately mimic the composition and behavior of natural cell membranes.

Basic Information

Product Name	Cholesterol, Water Soluble
CAS No.	69068-97-9
Molecular Formula	Typically a derivative of C27H46O (e.g., as a sulfate, phosphate, or PEGylated conjugate)
Molecular Weight	Varies by specific derivative. Contact for details.
Synonyms	Water-Soluble Cholesterol; Cholesterol Sulfate; Cholesterol Hemisuccinate; Cholesterol Phosphate; PEG-Cholesterol; Hydrophilic Cholesterol; Cholesterol Derivative for Aqueous Systems; Soluble Cholesterol Complex
EINECS	Contact for details.

Quality Control

Our Cholesterol, Water Soluble is produced and tested under a strict quality management system. Each batch is analyzed to ensure high purity, consistent solubility, and low levels of residual solvents or impurities. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (HPLC), identity (IR/NMR), water content, and heavy metals is provided with every shipment to guarantee traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect solubility and stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility in Water	Clear, colorless solution at specified concentration
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.