Description

N2-Isobutyryl-2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically a protected form of 2'-deoxyguanosine. This compound is of significant value as a critical building block and protecting group reagent in oligonucleotide synthesis, particularly for the production of antisense oligonucleotides and primers. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require high-purity intermediates for advanced nucleic acid chemistry and therapeutic development.

Application

• Oligonucleotide Synthesis: Serves as a key protected phosphoramidite precursor in solid-phase synthesis of DNA strands.
• Antisense Drug Development: Used in the manufacturing of antisense oligonucleotides for therapeutic applications targeting genetic diseases.
• PCR Primer Production: Acts as a modified nucleoside component in the synthesis of specialized primers for molecular diagnostics and research.
• Biochemical Research: Employed as a standard or reagent in studies of nucleic acid structure, function, and enzymatic processing.
• Probe Manufacturing: Utilized in the creation of labeled DNA probes for hybridization assays and genomic analysis.
• Pharmaceutical Intermediates: Functions as a high-purity intermediate in the synthesis of novel nucleoside-based antiviral or anticancer agents.

Basic Information

Product Name	N2-Isobutyryl-2'-Deoxyguanosine
CAS No.	68892-42-2
Molecular Formula	C15H21N5O5
Molecular Weight	351.36 g/mol
Synonyms	2'-Deoxy-N2-isobutyrylguanosine; 2'-Deoxyguanosine, N2-(2-methylpropanoyl)-; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(2-methylpropanoylamino)-1H-purin-2-one; N-Isobutyryl-2'-deoxyguanosine; dG(ib); N2-Ibu-dG; Protected 2'-Deoxyguanosine; Isobutyryl Deoxyguanosine Derivative
EINECS	Contact for details

Quality Control

Our N2-Isobutyryl-2'-Deoxyguanosine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring compliance with the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.