Description

5'-O-Dimethoxytrityl-N-Isobutyryl-Deoxyguanosine is a high-purity, protected nucleoside phosphoramidite precursor essential for automated oligonucleotide synthesis. This compound is critical for ensuring high coupling efficiency and sequence fidelity in the production of DNA and RNA strands. It is primarily required by pharmaceutical R&D, biotechnology companies, and diagnostic manufacturers for applications in antisense therapy, PCR primers, probes, and genetic research.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key building block (phosphoramidite precursor) in automated DNA/RNA synthesizers.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense oligonucleotides (ASOs), siRNA, and aptamers for drug development.
• Diagnostic Probe & Primer Synthesis: Fabrication of labeled probes and primers for PCR, qPCR, and genomic sequencing.
• Research-Grade Oligo Production: For academic and industrial research requiring custom DNA sequences.
• Synthesis of Modified Oligonucleotides: Enabling the incorporation of modified bases for enhanced stability or functionality.

Basic Information

Product Name	5'-O-Dimethoxytrityl-N-Isobutyryl-Deoxyguanosine
CAS No.	68892-41-1
Molecular Formula	C41H43N5O8
Molecular Weight	733.81 g/mol
Synonyms	5'-O-DMT-N2-Ibu-dG; DMT-dG(Ibu); N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine; 2'-Deoxyguanosine, N2-(2-methyl-1-oxopropyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-; DMTr-dG(ib); Protected Deoxyguanosine Monomer; dG-Ibu DMT; Guanosine, 2'-deoxy-, 5'-[bis(4-methoxyphenyl)phenylmethyl] ether, 2-[(2-methyl-1-oxopropyl)amino]-
EINECS	Contact for details

Quality Control

Our 5'-O-Dimethoxytrityl-N-Isobutyryl-Deoxyguanosine is manufactured under strict quality systems to meet the exacting standards of oligonucleotide synthesis. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, pyridine

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.