Description

2'-Iodo-2'-Deoxyadenosine is a halogenated nucleoside analog of significant interest in medicinal chemistry and life science research. This compound serves as a versatile building block for the synthesis of modified oligonucleotides and probes, enabling advanced studies in molecular biology and drug discovery. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic researchers focused on nucleic acid chemistry and antiviral or anticancer agent development.

Application

• Oligonucleotide Synthesis: A key intermediate for incorporating iodine-modified bases into DNA and RNA strands for structural studies, cross-linking experiments, and probe development.
• Antiviral/Anticancer Research: Serves as a precursor in the synthesis of nucleoside analogs being investigated for their therapeutic potential against viral infections and various cancers.
• Bioconjugation & Labeling: The iodine atom provides a handle for further functionalization via cross-coupling reactions (e.g., Sonogashira, Suzuki), useful for attaching fluorescent tags or other reporter molecules.
• Mechanistic Biochemistry Studies: Used to investigate enzyme mechanisms, particularly those of DNA polymerases and nucleoside kinases, due to its altered steric and electronic properties.
• Diagnostic Probe Development: Employed in creating specialized probes for detecting specific DNA/RNA sequences or for use in imaging applications.
• Radiolabeling Precursor: The iodine moiety can be exchanged for radioactive iodine isotopes (e.g., I-125) for use in tracer studies and radiopharmaceutical research.

Basic Information

Item	Details
Product Name	2'-Iodo-2'-Deoxyadenosine
CAS No.	68775-04-2
Molecular Formula	C10H11IN5O3
Molecular Weight	376.13 g/mol
Synonyms	9-[(2R,3S,5R)-3-Iodo-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-amine; 2'-Iodo-2'-deoxyadenosine; 2'-I-dA; 2'-Iododeoxyadenosine; 9-(3-Iodo-5-hydroxymethyl-2-tetrahydrofuryl)adenine; Adenosine, 2'-deoxy-2'-iodo-; 2'-Deoxy-2'-iodoadenosine
EINECS	Contact for details

Quality Control

Our 2'-Iodo-2'-Deoxyadenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.