Description

2' 3'-Dideoxyguanosine 5'-Triphosphate S is a modified nucleoside triphosphate analog, a critical biochemical reagent for molecular biology research. This compound serves as a chain terminator in enzymatic DNA sequencing and other nucleic acid synthesis applications, enabling precise genetic analysis. It is an essential tool for researchers and manufacturers in the fields of genomics, virology, and pharmaceutical development, particularly in studies involving reverse transcriptase and DNA polymerase mechanisms.

Application

• DNA Sequencing: Used as a chain-terminating substrate in Sanger (dideoxy) sequencing methods.
• Virology Research: Critical for studying the replication mechanisms of retroviruses and other viruses that utilize reverse transcriptase.
• Antiviral Drug Development: Serves as a reference standard or active pharmaceutical ingredient (API) intermediate in the development of nucleoside analog therapeutics.
• PCR and Related Techniques: Employed in specialized polymerase chain reaction (PCR) applications to study mutation rates and enzyme fidelity.
• Biochemical Assays: Utilized in in vitro assays to measure the activity and inhibition profiles of various DNA polymerases.
• Synthetic Biology: A building block for the controlled synthesis of modified oligonucleotides with specific termination properties.

Basic Information

Product Name	2' 3'-Dideoxyguanosine 5'-Triphosphate S
CAS No.	68726-28-3
Molecular Formula	C10H16N5O12P3
Molecular Weight	507.19 g/mol
Synonyms	2',3'-Dideoxyguanosine-5'-triphosphate; ddGTP; 2',3'-Dideoxy-GTP; Dideoxyguanosine triphosphate; 9-[(2R,3S,5R)-3-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-amino-1,9-dihydro-6H-purin-6-one 5'-(trihydrogen triphosphate); Guanosine, 2',3'-dideoxy-, 5'-(tetrahydrogen triphosphate)
EINECS	Contact for details

Quality Control

Every batch of 2' 3'-Dideoxyguanosine 5'-Triphosphate S is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive life science research. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Biological Activity	Suitable for use in DNA sequencing

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.