Description

Trifluoroacetyl Triflate is a highly reactive and versatile trifluoromethylating and acylating reagent. This compound is critical for introducing the trifluoroacetyl group into complex organic molecules, a key step in the synthesis of pharmaceuticals and advanced materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing carbon-carbon and carbon-heteroatom bonds under mild conditions.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of trifluoroacetylated active pharmaceutical ingredients (APIs) and advanced intermediates.
• Agrochemical Production: Used in the synthesis of fluorinated pesticides and herbicides, where the trifluoromethyl group enhances biological activity and stability.
• Catalyst and Ligand Preparation: Employed in the functionalization of catalysts and ligands to modify their electronic properties and reactivity.
• Material Science Research: Facilitates the synthesis of fluorinated polymers and organic electronic materials with unique properties.
• Peptide and Protein Modification: Acts as a selective acylating agent for amino groups in biochemical research.
• Cross-Coupling Reactions: Serves as an effective electrophile in palladium-catalyzed cross-coupling reactions to form aryl- and vinyl-CF3 bonds.

Basic Information

Product Name	Trifluoroacetyl Triflate
CAS No.	68602-57-3
Molecular Formula	C3F6O4S
Molecular Weight	246.09 g/mol
Synonyms	Trifluoromethanesulfonic Trifluoroacetic Anhydride; Trifluoroacetic Triflate; Trifluoroacetyl Trifluoromethanesulfonate; 2,2,2-Trifluoro-1-(trifluoromethylsulfonyloxy)ethanone; TFAT; (Trifluoroacetyloxy)trifluoromethanesulfonic Acid
EINECS	Contact for details

Quality Control

Our Trifluoroacetyl Triflate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and a strong acid/organic solvent; handle and store under an inert atmosphere (e.g., nitrogen or argon) in a dedicated cabinet for reactive chemicals.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (HPLC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.