Description

Bicyclo[2.2.2]octane-2-carbonyl chloride (9Ci) is a specialized bicyclic acid chloride derivative, serving as a crucial high-purity synthetic intermediate. Its rigid, three-dimensional bicyclo[2.2.2]octane scaffold makes it a valuable building block for constructing complex molecular architectures with defined spatial geometry. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring sterically constrained and conformationally locked structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring rigid, three-dimensional core structures to enhance binding affinity and metabolic stability.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides where the bicyclic framework can impart unique biological activity and environmental persistence profiles.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating sterically demanding ligands used in asymmetric catalysis and organometallic chemistry.
• Polymer and Material Science: Employed in the synthesis of specialty monomers for high-performance polymers, dendrimers, and cross-linked networks with tailored thermal and mechanical properties.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags that leverage its stable, hydrophobic core for studying protein-ligand interactions.
• Academic and R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic routes in organic chemistry.

Basic Information

Product Name	Bicyclo[2.2.2]octane-2-carbonyl chloride (9Ci)
CAS No.	68569-32-4
Molecular Formula	C9H11ClO
Molecular Weight	170.64 g/mol
Synonyms	2-Bicyclo[2.2.2]octanecarbonyl chloride; Bicyclo[2.2.2]octane-2-carboxylic acid chloride; 2-Carboxybicyclo[2.2.2]octane chloride; 2-BCO-COCl; NSC 338081; Bicyclo[2.2.2]octyl-2-carbonyl chloride; 2-(Chlorocarbonyl)bicyclo[2.2.2]octane
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.2]octane-2-carbonyl chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.