Description

3,N(4)-Ethenodeoxycytidine is a chemically modified nucleoside analog of deoxycytidine, featuring an etheno bridge between the N3 and C4 positions of the cytosine base. This structural modification is of significant interest in biochemical research for studying nucleic acid structure, mutagenesis, and the mechanisms of DNA damage and repair. It serves as a critical intermediate and reference standard in pharmaceutical development, particularly for antiviral and anticancer nucleoside analog prodrugs. Researchers and developers in the fields of medicinal chemistry, molecular biology, and analytical science require this high-purity compound for advanced studies and quality control applications.

Application

• Biochemical Research: Used as a probe to investigate DNA adduct formation, mutagenic processes, and the structural dynamics of nucleic acids.
• Pharmaceutical Reference Standard: Serves as a critical analytical standard for the development, validation, and quality control of novel nucleoside-based therapeutics.
• Medicinal Chemistry Intermediate: Acts as a key synthetic building block in the research and development of antiviral and anticancer prodrug candidates.
• Toxicology Studies: Employed in studies assessing the genotoxic effects of environmental alkylating agents and related compounds.
• Enzymology: Utilized as a substrate or inhibitor in studies of enzymes involved in nucleotide metabolism and DNA repair pathways.
• Diagnostic Development: Potential use in the development of diagnostic assays for detecting specific types of DNA damage.

Basic Information

Item	Details
Product Name	3,N(4)-Ethenodeoxycytidine
CAS No.	68498-26-0
Molecular Formula	C11H15N3O4
Molecular Weight	253.25 g/mol
Synonyms	1,N6-Etheno-2'-deoxycytidine; 3,N4-Etheno-2'-deoxycytidine; 1,N6-Etheno-2'-deoxycytidine; εdCyd; 3,N4-α-Etheno-2'-deoxycytidine; 3,N4-Ethenocytidine deoxyriboside; 2'-Deoxy-3,N4-ethenocytidine
EINECS	Contact for details

Quality Control

Our 3,N(4)-Ethenodeoxycytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (NMR, IR, MS), and determination of residual solvents and moisture content to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.