Description

1,N6-Etheno-2'-Deoxy-Adenosine is a chemically modified nucleoside analog of deoxyadenosine, featuring an etheno bridge between the N1 and C6 positions of the adenine base. This structural modification is critical for its role as a stable biomarker and a valuable research tool in the study of DNA damage and mutagenesis. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in toxicology studies, biomarker analysis, and nucleic acid chemistry.

Application

• Biomarker Research: Used as a stable reference standard for the detection and quantification of etheno-DNA adducts, which are indicators of oxidative stress and lipid peroxidation damage in genetic material.
• Toxicology and Carcinogenesis Studies: Essential for investigating the mechanisms of DNA damage induced by environmental toxins, such as vinyl chloride and other carcinogens, and for assessing associated cancer risks.
• Diagnostic Assay Development: Serves as a key calibrant and control in the development of highly sensitive analytical methods, including LC-MS/MS and immunoassays, for monitoring DNA adducts in biological samples.
• Nucleic Acid Chemistry: Employed in synthetic organic chemistry and biochemistry as a building block or probe to study DNA structure, function, and repair pathways.
• Pharmaceutical Research: Used in early-stage drug discovery to evaluate compounds designed to prevent or repair specific types of DNA damage.

Basic Information

Product Name	1,N6-Etheno-2'-Deoxy-Adenosine
CAS No.	68498-25-9
Molecular Formula	C12H13N5O3
Molecular Weight	275.26 g/mol
Synonyms	1,N6-Etheno-2'-deoxyadenosine; 1,N6-Ethenodeoxyadenosine; εdA; 1,N6-Etheno-dA; 2'-Deoxy-1,N6-ethenoadenosine; Etheno-dAdo; 1,N6-Etheno-2'-deoxyadenosine (εdAdo); DNA Adduct εdA
EINECS	Contact for details

Quality Control

Our 1,N6-Etheno-2'-Deoxy-Adenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC and other spectroscopic methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.