Description

2-Pyrrolidinecarbonylchloride,1-Methyl-3-Propyl-,(2S-Trans)-(9Ci) is a high-purity, chiral organic intermediate of significant importance in advanced synthetic chemistry. Its value lies in its role as a key building block for the construction of complex, stereochemically defined molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Used as a precursor for chiral auxiliaries, ligands, or catalysts in stereoselective chemical transformations.
• Peptidomimetic Research: Serves as a constrained proline analogue for the design and synthesis of novel peptidomimetics and protease inhibitors.
• Agrochemical Development: Employed in the synthesis of advanced, chiral active ingredients for crop protection products.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Pyrrolidinecarbonylchloride,1-Methyl-3-Propyl-,(2S-Trans)-(9Ci)
CAS No.	68326-15-8
Molecular Formula	C9H16ClNO
Molecular Weight	189.68 g/mol
Synonyms	(2S)-1-Methyl-3-propylpyrrolidine-2-carbonyl chloride; (2S-trans)-1-Methyl-3-propyl-2-pyrrolidinecarbonyl chloride; L-Proline, 1-methyl-3-propyl-, 1-chlorocarbonyl- (9CI); 1-Methyl-3-propyl-L-proline chloride; (S)-1-Methyl-3-propylpyrrolidine-2-carboxylic acid chloride; 68326-15-8; (2S)-1-Methyl-3-propyl-2-pyrrolidinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-Pyrrolidinecarbonylchloride,1-Methyl-3-Propyl-,(2S-Trans)-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. All materials are fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/GC), chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.