Description

1-(2'-Tetrahydrothienyl) 5-Fluorouracil is a fluorinated pyrimidine derivative and a key pharmaceutical intermediate. This compound is valued for its role in the synthesis of more complex, biologically active molecules, particularly in oncology research and development. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the creation of novel chemotherapeutic agents and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced fluorouracil prodrugs and antimetabolite chemotherapeutic agents.
• Oncology Research: Used in preclinical and discovery-phase research for developing new cancer treatments targeting DNA synthesis and cell proliferation.
• Prodrug Development: Serves as a precursor molecule for designing prodrugs with improved bioavailability, tumor selectivity, and reduced systemic toxicity.
• Biochemical Research: Employed in studies investigating the mechanisms of action of fluoropyrimidines and their interactions with thymidylate synthase.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1-(2'-Tetrahydrothienyl) 5-Fluorouracil
CAS No.	68321-44-8
Molecular Formula	C9H11FN2O2S
Molecular Weight	230.26 g/mol
Synonyms	1-(Tetrahydro-2-thienyl)-5-fluorouracil; 5-Fluoro-1-(tetrahydro-2-thienyl)uracil; 1-(Tetrahydrothiophen-2-yl)-5-fluorouracil; 5-FU-THT; FT-207 analogue; Tegafur intermediate; N1-(2'-Tetrahydrofuryl)-5-fluorouracil analogue; 1-(2'-Tetrahydrothienyl)-5-FU
EINECS	Contact for details

Quality Control

Our 1-(2'-Tetrahydrothienyl) 5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider conditions under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.