Description

(6,11,16A)-9-Fluoro-6,11-Dihydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-3,20-Dioxopregna-1,4-Dien-21-Oic Acid is a high-purity synthetic steroid derivative with a complex, multi-functional molecular structure. This compound is of significant value as a critical pharmaceutical intermediate, enabling the synthesis of advanced corticosteroid-based active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories and manufacturing facilities focused on developing and producing potent anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced corticosteroid drugs.
• Anti-inflammatory Drug Development: Used in research and production of novel topical and systemic anti-inflammatory agents.
• Immunosuppressant Synthesis: Serves as a precursor for APIs used in treatments for autoimmune diseases and organ transplant rejection.
• Dermatological Preparations: Incorporated into the development of high-potency creams and ointments for severe skin conditions.
• Chemical Reference Standard: Employed as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.
• Academic & Industrial Research: Utilized in medicinal chemistry programs to study structure-activity relationships (SAR) of fluorinated steroids.

Basic Information

Item	Detail
Product Name	(6,11,16A)-9-Fluoro-6,11-Dihydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-3,20-Dioxopregna-1,4-Dien-21-Oic Acid
CAS No.	68263-02-5
Molecular Formula	C26H31FO8
Molecular Weight	490.52 g/mol
Synonyms	9-Fluoro-6,11-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3,20-dioxopregna-1,4-dien-21-oic acid; 9-Fluoro-6,11,16,17-Tetrahydroxyprednisolone 16,17-Acetonide 21-Carboxylic Acid; Fluocinolone Acetonide Related Compound; Fluocinolone Acetonide Carboxylic Acid; 6,11-Dihydroxy-9-fluoro-16,17-[(1-methylethylidene)bis(oxy)]-3,20-dioxopregna-1,4-dien-21-oic acid; 21-Carboxyfluocinolone Acetonide; 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 6-acetate (related compound)
EINECS	Contact for details

Quality Control

Our (6,11,16A)-9-Fluoro-6,11-Dihydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-3,20-Dioxopregna-1,4-Dien-21-Oic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications suitable for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.