Description

6-Iodomethylcholesterol is a high-value, functionalized sterol derivative, specifically designed for advanced chemical synthesis and research applications. This compound serves as a critical intermediate for the site-specific introduction of cholesterol moieties into complex molecules, enabling the study of lipid metabolism, membrane biophysics, and targeted drug delivery systems. It is essential for pharmaceutical R&D, academic research in biochemistry, and the development of diagnostic agents and novel biomaterials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel cholesterol-based therapeutics and prodrugs targeting lipid disorders.
• Bioconjugation & Labeling: Used to covalently attach cholesterol tags to peptides, proteins, or nanoparticles for cellular targeting and tracking studies.
• Lipid Membrane Research: A crucial tool for modifying liposomes and studying cholesterol's role in membrane fluidity, raft formation, and protein function.
• Diagnostic Agent Synthesis: Intermediate in the production of radiolabeled (e.g., with I-125) cholesterol analogs for imaging and diagnostic applications.
• Biomaterial Functionalization: Employed to introduce hydrophobic anchors onto polymer backbones or surfaces to create biomimetic materials.
• Chemical Biology Probes: Facilitates the creation of activity-based probes to investigate sterol-interacting proteins and enzymes in metabolic pathways.

Basic Information

Product Name	6-Iodomethylcholesterol
CAS No.	68232-36-0
Molecular Formula	C28H47IO
Molecular Weight	526.58 g/mol
Synonyms	6-(Iodomethyl)cholest-5-en-3β-ol; 3β-Hydroxy-6-(iodomethyl)cholest-5-ene; Cholest-5-en-3β-ol, 6-(iodomethyl)-; 6-Iodomethyl-cholesterol; 6-IMC; 6-Iodo-methyl cholesterol; 6-(Iodomethyl)-3β-hydroxycholest-5-ene
EINECS	Contact for details

Quality Control

Every batch of 6-Iodomethylcholesterol (CAS 68232-36-0) is manufactured and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development work. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically verified by HPLC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.