Description

5'-Deoxy-5'-Iodoguanosine is a chemically modified nucleoside derivative where the 5'-hydroxyl group of guanosine is replaced by an iodine atom. This specific halogenation makes it a valuable synthetic intermediate and research chemical in the development of novel antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on nucleoside chemistry and medicinal chemistry. The compound's structure allows for further functionalization, enabling the synthesis of targeted probes and potential therapeutic candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analog drugs targeting viral infections and cancer.
• Medicinal Chemistry Research: Used as a precursor for creating modified oligonucleotides and probes to study biological mechanisms.
• Biochemical Tool Development: Employed in the development of labeled nucleotides for diagnostic assays and imaging studies.
• Antiviral Agent Development: Serves as a core structure for research into compounds that inhibit viral polymerase enzymes.
• Academic & Industrial R&D: Fundamental reagent in laboratories exploring structure-activity relationships (SAR) of nucleosides.

Basic Information

Product Name	5'-Deoxy-5'-Iodoguanosine
CAS No.	68200-68-0
Molecular Formula	C10H12IN5O4
Molecular Weight	393.14 g/mol
Synonyms	5'-Iodo-5'-deoxyguanosine; 9-[(5-Deoxy-5-iodo-β-D-ribofuranosyl)]guanine; 5'-Deoxy-5'-iodoguanosine; Guanosine, 5'-deoxy-5'-iodo-; 5'-Iodoguanosine; 5'-Iodo-2'-deoxyguanosine (common misnomer, verify structure); 5'-Deoxy-5'-iodo-guanosine
EINECS	Contact for details

Quality Control

Our 5'-Deoxy-5'-Iodoguanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.