Description

2'-Amino-2'-Deoxy--D-Arabinouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a crucial building block for the synthesis of novel antiviral and anticancer agents, particularly in the design of oligonucleotide therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry. The high-purity material enables precise molecular modifications essential for developing next-generation targeted therapies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Building block for constructing modified DNA/RNA strands in antisense and siRNA therapeutic development.
• Biochemical Research: Tool compound for studying enzyme mechanisms, particularly nucleoside kinases and polymerases.
• Medicinal Chemistry: Scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: High-purity material for analytical method development and quality control in API manufacturing.
• Prodrug Development: Starting material for creating prodrugs with improved bioavailability and pharmacokinetic profiles.

Basic Information

Product Name	2'-Amino-2'-Deoxy--D-Arabinouridine
CAS No.	68115-81-1
Molecular Formula	C9H13N3O5
Molecular Weight	243.22 g/mol
Synonyms	2'-Amino-2'-deoxyarabinouridine; 1-((2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(2-hydroxyethyl)oxolan-2-yl)pyrimidine-2,4-dione; 2'-Amino-arabinouridine; 2'-NH2-araU; AraU-NH2; β-D-Arabinofuranosyl-2-aminouracil; 2-Amino-1-β-D-arabinofuranosyluracil
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxy--D-Arabinouridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.