Description

2,2,6,6-Tetramethylpiperidine-4-Carbonyl Chloride is a highly reactive and versatile acyl chloride derivative of the hindered amine 2,2,6,6-tetramethylpiperidine. This compound matters as a critical building block for synthesizing advanced materials and pharmaceutical intermediates, where its sterically hindered structure imparts unique stability and performance characteristics. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and polymer industries for creating novel compounds, including hindered amine light stabilizers (HALS) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly those requiring sterically hindered amine motifs.
• Hindered Amine Light Stabilizer (HALS) Synthesis: Serves as a fundamental building block for manufacturing high-performance HALS, which are essential additives to prevent polymer degradation from UV light.
• Agrochemical Active Ingredient Production: Used in the research and development of advanced pesticides and herbicides, where the tetramethylpiperidine moiety can enhance biological activity and stability.
• Advanced Material Research: Employed in creating novel polymers, coatings, and functional materials that benefit from the incorporation of a bulky, stable amine derivative.
• Chemical Synthesis Reagent: Acts as an acylating agent in organic synthesis to introduce the 2,2,6,6-tetramethylpiperidine-4-carbonyl group into target molecules under controlled conditions.
• Ligand and Catalyst Development: Utilized for constructing sophisticated ligands and organocatalysts used in asymmetric synthesis and other specialized chemical transformations.

Basic Information

Product Name	2,2,6,6-Tetramethylpiperidine-4-Carbonyl Chloride
CAS No.	67846-00-8
Molecular Formula	C10H18ClNO
Molecular Weight	203.71 g/mol
Synonyms	4-Piperidinecarbonyl chloride, 2,2,6,6-tetramethyl-; 2,2,6,6-Tetramethyl-4-piperidinecarbonyl chloride; 4-(Chlorocarbonyl)-2,2,6,6-tetramethylpiperidine; TMCP-Cl; TMP-COCl; Tetramethylpiperidine-4-carbonyl chloride; 4-Carboxy-2,2,6,6-tetramethylpiperidine chloride
EINECS	Contact for details

Quality Control

Our 2,2,6,6-Tetramethylpiperidine-4-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and titration to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in GMP-compliant pharmaceutical synthesis and advanced material research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.