Description

9-(2-Sulfo)-Fluorenylmethyloxycarbonyl Chloride is a specialized, activated sulfonated derivative of the classic Fmoc protecting group. This compound matters for its enhanced solubility in aqueous and polar organic solvent systems, making it a critical reagent for the synthesis of peptides and other biomolecules under mild, water-compatible conditions. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in advanced solid-phase peptide synthesis (SPPS) and the development of sensitive bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a water-soluble amino-protecting group reagent for the introduction of the Fmoc group onto amino acids, particularly valuable for synthesizing hydrophilic or challenging peptide sequences.
• Bioconjugation Chemistry: Used to modify biomolecules such as proteins, antibodies, or oligonucleotides with fluorescent tags, affinity labels, or drug payloads via amine-reactive chemistry.
• Linker and Scaffold Functionalization: Employed in the preparation of functionalized polymeric supports, dendrimers, and molecular scaffolds for combinatorial chemistry and drug discovery libraries.
• Protecting Group Strategy: Facilitates the orthogonal protection of amines in complex multi-step organic syntheses, especially where aqueous workup conditions are preferred.
• Proteomics Research: A key tool for the chemical modification and labeling of peptides in mass spectrometry-based proteomic analysis.
• Diagnostic Reagent Manufacturing: Serves as an intermediate in the production of specialized reagents for clinical diagnostics and assay development.

Basic Information

Product Name	9-(2-Sulfo)-Fluorenylmethyloxycarbonyl Chloride
CAS No.	67827-06-9
Molecular Formula	C₁₆H₁₁ClO₅S
Molecular Weight	350.77 g/mol
Synonyms	Fmoc-OSu Sulfonate; 9-Fluorenylmethyl N-succinimidyl sulfonate carbonate chloride; 2-Sulfo-9-fluorenylmethoxycarbonyl Chloride; Sulfonated Fmoc-Cl; S-Fmoc Chloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyloxy]sulfosuccinimide Chloride; 9-Fluorenylmethyloxycarbonylsulfonyl Chloride (informal); Fmoc-sulfonyl chloride derivative
EINECS	Contact for details

Quality Control

Our 9-(2-Sulfo)-Fluorenylmethyloxycarbonyl Chloride is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.