Description

(2S)-3,4,4A,10Aβ-Tetrahydro-4β-Hydroxy-3α,4Aβ-Dimethoxy-2β-Methyl-9-(2-Pyridinyl)-2H-Pyrano[3',2':5,6][1,4]Dioxino[2,3-C]Pyridine-7-Carbaldehyde (E)-Oxime is a complex, high-purity heterocyclic compound with a defined stereochemistry, serving as a critical advanced intermediate in pharmaceutical research and development. Its intricate fused-ring structure makes it a valuable scaffold for synthesizing novel bioactive molecules targeting specific receptors and enzymes. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly for projects involving central nervous system (CNS) agents or anti-infective drugs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in neurological and psychiatric therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Reference Standard: High-purity material for analytical method development, validation, and quality control of related active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Potential use in pharmacological assays to study specific biological pathways and protein interactions.
• Custom Synthesis: Starting point for the contract manufacturing of specialized, non-commercial chemical entities for client-specific R&D projects.

Basic Information

Product Name	(2S)-3,4,4A,10Aβ-Tetrahydro-4β-Hydroxy-3α,4Aβ-Dimethoxy-2β-Methyl-9-(2-Pyridinyl)-2H-Pyrano[3',2':5,6][1,4]Dioxino[2,3-C]Pyridine-7-Carbaldehyde (E)-Oxime
CAS No.	67819-78-7
Molecular Formula	C₂₃H₂₅N₃O₇
Molecular Weight	455.47 g/mol
Synonyms	9-(2-Pyridinyl)-2H-pyrano[3',2':5,6][1,4]dioxino[2,3-c]pyridine-7-carbaldehyde, (2S,3R,4R,4aR,10aR)-4-hydroxy-3,4a-dimethoxy-2-methyl-3,4,4a,10a-tetrahydro-, (E)-oxime; (E)-((2S,3R,4R,4aR,10aR)-4-Hydroxy-3,4a-dimethoxy-2-methyl-3,4,4a,10a-tetrahydro-9-(pyridin-2-yl)-2H-pyrano[3',2':5,6][1,4]dioxino[2,3-c]pyridin-7-yl)methanone oxime; CAS 67819-78-7; 67819-78-7.
EINECS	Contact for details

Quality Control

Our production of (2S)-3,4,4A,10Aβ-Tetrahydro-4β-Hydroxy-3α,4Aβ-Dimethoxy-2β-Methyl-9-(2-Pyridinyl)-2H-Pyrano[3',2':5,6][1,4]Dioxino[2,3-C]Pyridine-7-Carbaldehyde (E)-Oxime adheres to stringent quality management systems, ensuring batch-to-batch consistency suitable for pharmaceutical R&D. Products undergo rigorous analytical testing, including HPLC for purity, chiral methods for stereochemical confirmation, and comprehensive identification protocols. A detailed Certificate of Analysis (COA) is provided with each batch, documenting all critical quality attributes. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.