Description

Guanosine-3',5'-Cyclic Phosphorothioate CAS NO 67736-26-9 is a chemically modified nucleotide analog where a sulfur atom replaces one of the non-bridging oxygen atoms in the cyclic phosphate group. This modification makes it a valuable, non-hydrolyzable analog of cyclic GMP (cGMP), serving as a crucial tool for probing signal transduction pathways. It is primarily utilized in biochemical and pharmacological research to study the role of cGMP-dependent protein kinases (PKG) and phosphodiesterases. This high-purity compound is essential for researchers and manufacturers in the life sciences, pharmaceutical development, and diagnostic reagent sectors.

Application

• Biochemical Research: Acts as a stable, hydrolysis-resistant activator of cGMP-dependent protein kinases (PKG) in cell signaling studies.
• Pharmaceutical Screening: Used as a reference standard and tool compound in high-throughput screening assays for drug discovery targeting the cGMP pathway.
• Enzyme Studies: Serves as a substrate analog to investigate the specificity and inhibition of phosphodiesterases (PDEs).
• Cell Biology: Employed in studies of cellular processes such as smooth muscle relaxation, platelet aggregation, and neuronal signaling.
• Diagnostic Development: Potential use in the development of calibration standards for diagnostic assays measuring cGMP-related biomarkers.
• Academic Research: A key reagent for universities and research institutes studying cardiovascular, neurological, and metabolic disorders.

Basic Information

Product Name	Guanosine-3',5'-Cyclic Phosphorothioate
CAS No.	67736-26-9
Molecular Formula	C10H12N5O6PS
Molecular Weight	361.27 g/mol
Synonyms	cGMPS; Guanosine 3',5'-cyclic monophosphorothioate; Cyclic GMP phosphorothioate; 8-Br-cGMPS (common derivative); Guanosine cyclic 3',5'-(hydrogen phosphorothioate); Rp-isomer (common stereoisomer); Sp-isomer (common stereoisomer); cGMP-S
EINECS	Contact for details

Quality Control

Our Guanosine-3',5'-Cyclic Phosphorothioate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.