Description

4-Fluoro-3-(trifluoromethyl)benzoyl chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in introducing both a reactive acyl chloride group and a trifluoromethyl-fluorophenyl moiety, which are key for modifying the physical and biological properties of target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce fluorinated aromatic units into polymer chains, improving chemical resistance, thermal stability, and surface properties.
• Dye & Pigment Manufacturing: Acts as an intermediate for synthesizing specialized fluorinated dyes and pigments with enhanced lightfastness and color properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)benzoyl chloride
CAS No.	67515-56-4
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	4-Fluoro-3-(trifluoromethyl)benzoyl chloride; 3-Trifluoromethyl-4-fluorobenzoyl chloride; 4-Fluoro-alpha,alpha,α-trifluoro-m-toluoyl chloride; 4-Fluoro-3-trifluoromethylbenzoyl chloride; 67515-56-4; Benzoyl chloride, 4-fluoro-3-(trifluoromethyl)-; m-Toluoyl chloride, 4-fluoro-alpha,alpha,α-trifluoro-
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-3-(trifluoromethyl)benzoyl chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at 15-25°C. This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and ensure long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.